Non reactivity exercises12/27/2023 ![]() Despite this beneficial role, it is crucial to balance or scavenge the ROS otherwise, it could lead to damage within the cellular structure. It is now known that ROS play a vital role in cellular function in terms of acting as a signaling molecule. After that, several reports on the harmful effects of ROS have been continuously described ( Schieber and Chandel, 2014 Pizzino et al., 2017). The free radical theory of aging was originally described in the 1950s by Denham Harman ( Harman, 1956). ![]() However, moderate to extreme running may damage cellular structure by inducing reactive oxygen species (ROS) production ( Parker et al., 2018). ![]() Due to easy accessibility, many people start as recreational runners with a goal to improve health and exercise benefits geared toward disease prevention and incremental progress in physical fitness. Results: Outcomes included (1) running programs like a half-marathon, ultramarathon, and iron-man race, (2) measuring biochemical assessment of oxidative damage markers such as malondialdehyde (MDA), protein carbonyl (PC), total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), 8-Oxo-2'-deoxyguanosine (8-OH-dG), 4-hydroxynonenal (HNE), and F1-isoprostones, and enzymatic and non-enzymatic antioxidants level.Ĭonclusions: This study concluded that a running exercise does not elicit a response to specific biomarkers of oxidative stress, instead, oxidative damage markers of lipids, proteins, and various enzymatic and non-enzymatic antioxidants are expressed according to the training status of the individual.Įxercise induced health benefits are well-known realities that have positively impacted peoples' lives in terms of reducing or preventing non-communicable diseases such as obesity, cardiovascular diseases, and other chronic health problems ( Knez et al., 2006). Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using related search terms such as oxidative damage, ROS, exercise, physical training, running, marathon, and ultramarathon. Objective: The purpose of this study was to systematically investigate the suitable biomarkers that predict oxidative stress status among runners. However, predicting ROS induced oxidative stress in response to endurance training has several limitations in terms of selecting biomarkers that are used to measure oxidative stress. ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. 4Faculty of Engineering, University of Szeged, Szeged, Hungaryīackground: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS).3School of Health and Life Sciences, University of the West of Scotland, Scotland, United Kingdom.2Laboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil. ![]() ![]() 1Faculty of Sports Science, Ningbo University, Ningbo, China.Ugbolue 3, Yuhuan He 1, Yao Meng 4 and Yaodong Gu 1 * ![]()
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